Mus Identified Again/ Sleep Deprivation/ Arrest Programer

Slumber is as essential to our daily needs equally food and water. Although we may feel that sleep simply rests our tired bodies, our brain remains active throughout the dark. Sleep plays a critical office in brain as well every bit physical functioning.

What Happens When We Sleep?

Our internal body clock, called a circadian clock, tells us when nosotros are ready to slumber. There are actually several circadian clocks in the torso, establish in the brain and other organs. They are triggered by cues such as daylight (we experience alert) and darkness (nosotros experience drowsy). These clocks tin can also exist triggered by artificial bright light or stimulants similar caffeine and booze that cause u.s.a. to feel awake fifty-fifty if it is nighttime.

There are several phases of sleep our trunk experiences. They are classified as REM (rapid eye motion) and non-REM sleep. Nosotros cycle repeatedly through these phases most 4-6 times throughout the night, and it is not uncommon to wake up briefly between cycles.

Non-REM sleep

Stage i. You transition from beingness awake to a restful state.

Phase 2. Y'all are in a light sleep state. Your breathing, heart rate, and muscle movements tedious down. Brain activity also slows, and your body temperature drops.

Stage 3. Y'all are in a deep sleep land. This phase often occurs early in the sleep cycle immediately following light sleep. Your heart rate and breathing are the slowest during this phase, and you are not hands awakened. Events of the mean solar day are processed and stored in your retentivity. A lack of deep sleep tin can leave 1 feeling tired in the forenoon even if achieving an adequate duration of sleep.

REM sleep

During REM, your pupils twitch and move quickly from side to side underneath airtight eyelids. Brain action rises as y'all breathe faster and your heart rate increases. It is the stage of sleep when dreams are most mutual, and sure nerves signal your limbs to become temporarily paralyzed and so you do non act out the dream. REM tends to occur later at night and into early morning time. Retentivity is candy and stored during REM sleep.

Why do we dream?

Dreams occur during the REM sleep stage and may include events or thoughts you experienced recently. Dreams may occur to help process emotions caused by those events. People written report dreaming in vivid color also as in blackness and white. Sometimes even a wild crazy dream can be forgotten by the time we awaken in the forenoon.

Hormones that Regulate Sleep Cycles

In that location are various neurotransmitters and hormones released by the brain that send signals to promote sleep or wakefulness. [1] Many of these chemicals are stimulated by light or darkness.

• GABA is a neurotransmitter that decreases nerve prison cell activity, playing a major role in allowing the body to sleep.
• Adenosine is another neurotransmitter that gradually accumulates in the brain during the day, and at high concentrations makes us sleepy at night. Caffeine in coffee and other beverages can continue us awake as it blocks encephalon receptors for adenosine.
• Melatonin is a hormone released by the encephalon when it is dark. Information technology travels to cells to tell the trunk to sleep. Sunlight or exposure to light inhibits the production of melatonin and increases the release of cortisol, which awakens united states of america. If we are exposed to too much artificial light (such as the blue calorie-free emitted from smartphones or televisions) late at nighttime, less melatonin may be released making it harder to fall asleep.
• Serotonin, the body'south "feel-good" chemical, is a neurotransmitter associated with both sleep and being awake. The encephalon releases this chemic during daylight but also uses it to form melatonin at night.
• Hormones that counteract sleep include norepinephrine, adrenaline, histamine, and cortisol. These are secreted in response to stress and crusade the torso to be awake and alert. If ane experiences prolonged or chronic stress, the body releases adrenocorticotropic hormone (ACTH), which in plough releases cortisol. Levels of ACTH tend to be higher in people who take insomnia.

Immediate Effects of Slumber Impecuniousness

About 1-tertiary of American adults practice not get enough sleep each nighttime, according to the Centers for Disease Control and Prevention. [2,three] Curt slumber duration in adults is defined as less than seven hours of sleep in 24 hours. Almost 40% of adults study unintentionally falling asleep during the day at least once a month, and upwardly to seventy million Americans have chronic sleep problems. Considering of the public health brunt of poor slumber wellness, achieving sufficient slumber in children and adults was included every bit a goal in the Healthy People 2022 goals. [4]

Sleep helps to process your thoughts from the day also as store memories, so a lack of good-quality sleep can lead to difficulty focusing and thinking clearly. You may feel tired, irritable, or anxious during the solar day. Functioning at piece of work or schoolhouse may suffer. Your reaction time may be slowed, increasing the risk of driving accidents.

In children, bereft sleep can lead to attention and behavior problems or hyperactivity. In the elderly, lack of sleep may subtract focus and attention, leading to a greater risk of falls, bone fractures, and automobile accidents.

There are several reasons people may get bereft sleep:

• Poor sleep habits (watching boob tube or using screens late at night, drinking caffeinated or alcoholic beverages at night, not following a regular sleep schedule).
• Your sleep environment is besides noisy, also light or otherwise non conducive to sleep.
• Y'all attempt to sleep outside of the torso's natural circadian clock (working an overnight shift and trying to make upwardly for slumber during the 24-hour interval).
• You have a sleep disorder, such as slumber apnea, indisposition, or periodic limb movements that reduces deep or REM slumber or causes frequent awakenings.
• You lot accept a medical status such as eye, lung or kidney illness, or chronic pain, which causes frequent awakenings.

Sleep Deficiency and Disease Risk

If yous experience connected sleep deprivation, you volition develop a condition called sleep deficiency. This is a state in which you cannot make up the many lost hours of sleep. Sleep deficiency increases the chance of obesity, diabetes, cardiovascular illness, low, and fifty-fifty early death.

Obesity

Several studies testify that slumber deprivation (i.e., regularly less than 7 hours of sleep a night) is a chance factor for obesity. A Nurses' Wellness Study found an clan between those who slept the to the lowest degree (5 hours or less a night) and having the highest BMI and greatest weight proceeds. [5] I reason may be a disruption in appetite hormones that regulate feelings of hunger (called ghrelin) versus satisfaction (called leptin). Ghrelin levels rise while leptin levels driblet with lack of sleep; this can cause college calories to be consumed due to experiencing potent hunger at the same fourth dimension that one feels less satiated after eating. A preference for foods loftier in fatty and carbohydrate has been observed. [half dozen,vii] The take a chance of hunger also increases simply by beingness awake longer, which prolongs the time from the concluding meal eaten to bedtime. [half-dozen] Insufficient sleep also can trigger the "reward" areas in your encephalon to crave high fat, high caloric foods. [8]

One may retrieve that getting less sleep would mean more activeness due to being awake longer and therefore using more calories. However, studies have plant either no increase or very small increases in energy expenditure with sleep impecuniousness, and fifty-fifty a tendency towards reduced physical activity due to fatigue. [nine] Less physical activity combined with the increased calorie intake associated with slumber deprivation increases the risk of obesity.

Other furnishings of poor slumber include increased fat storage in the belly expanse, higher body mass index, poorer quality diet, and decreased insulin sensitivity. [6,10] Interestingly, some studies accept also shown that longer sleep times (more 9 hours) are also associated with developing abdomen fat compared with sleeping 7-viii hours a nighttime. [7]

Diabetes

Epidemiological and laboratory studies bear witness a higher risk of diabetes mellitus with both as well little sleep (less than 7 hours) and longer slumber durations (more than 9 hours). Metabolic changes may occur with chronic insufficient sleep, such as college cortisol levels leading to increased claret glucose. Clinical studies have found both increased glucose and insulin levels (suggesting insulin resistance) and reduced insulin sensitivity in sleep-deprived individuals. [11] Disruption in the regulation of appetite hormones as seen with higher ghrelin and lower leptin levels may lead to increased nutrient intake and weight gain, as well increasing the risk of insulin resistance. [11]

Some people who have insufficient slumber take a condition called obstructive slumber apnea, which blocks breathing in the upper airway tubes, often considering of increased fatty in the tongue. Sleep apnea is independently associated with insulin resistance; a lack of oxygen while sleeping tin can crusade oxidative stress and inflammation that are believed to progress toward insulin resistance. [eleven]

Cardiovascular affliction

Both shorter and longer sleep durations are associated with cardiovascular diseases. [12,thirteen] Proposed reasons include activation of the sympathetic nervous system and impaired endothelial function, which tin can lead to elevated blood force per unit area and hardening of arteries. There may as well be greater release of pro-inflammatory cells and decreased immune function. Metabolic changes include a disruption in appetite hormones and circadian rhythms that lead to inflammatory conditions. [14]

• People sleeping less than 6 hours a nighttime, peculiarly women, were xx-32% more likely to develop hypertension compared with those sleeping 7-viii hours a nighttime. [12] Having v or less hours of sleep a nighttime was associated with double the risk of developing hypertension in another study. [15]
• In a Nurses' Health Study, the risk of heart illness was almost one.four times higher in women sleeping 5 hours or less a nighttime and ix hours or more a nighttime compared with those sleeping 8 hours a night. [16]
• In postmenopausal women, those who slept 5 hours or less or 10 hours or more than a night had a 25% and 45% increased chance of eye disease, respectively. [17]
• Individuals with inadequate sleep likewise equally long sleep durations showed an increased chance of strokes. [12]
• Individuals with poor sleep quality or insomnia symptoms are twoscore% more probable to develop hypertension [eighteen]
• People with obstructive sleep apnea are at increased risk for stroke, center attack, and center failure.

Low

Poor sleep and insomnia (an disability to sleep or stay asleep) are associated with depression, especially if the insomnia becomes chronic. [xix] Indisposition is also associated with increased likelihood of insomnia relapsing over fourth dimension. Poor slumber quality can impair functioning, increment fatigue, and atomic number 82 to mood changes. The contrary is also true in which depressive symptoms of intense sadness or hopelessness can interrupt sleep. Insomnia too as oversleeping are common signs of clinical depression, according to the National Institute of Mental Health. [twenty] Treating the low may lead to improvements in slumber quality. If there is an underlying medical disorder causing the insomnia such equally obstructive sleep apnea or chronic pain, and so treatment should address these showtime.

Dementia

In 2021, authors of a cohort study sought to tease out the association of early brain changes and sleep changes past including younger patients 50 years of age. They followed 7,959 participants for up to 25 years and establish that participants who were betwixt the ages of 50-lxx years and slept 6 hours or less a night showed a 30% college risk of developing dementia in later on life, compared with those who slept seven hours. [39] The clan was only slightly weaker when authors controlled for various factors independently associated with dementia like cardiometabolic status (loftier blood pressure, diabetes mellitus, trunk mass alphabetize, cardiovascular illness), sociodemographic variables (age, sex, ethnicity, education, marital condition), health behaviors (smoking, alcohol, exercise, intake of fruits and vegetables), and mental health factors (depression). The authors did not find an association with longer sleep durations (viii or more than hours) and dementia, though this may have been due to the depression number of participants who slept longer durations.

Mortality

Prospective cohort studies take plant that both a chronic lack of sleep (less than seven hours) and long sleep durations (more than than eight hours) are associated with greater risk of death from all causes. [7,13] Obstructive sleep apnea and indisposition are also associated with increased bloodshed. [21,22]Even so, long sleep durations appear to be more than associated with increased risk of mortality than inadequate sleep. [thirteen] Some studies show that women may have greater risk of bloodshed related to short sleep durations than men. [23] Longer sleep times are associated with several factors that are associated with mortality, including fatigue, stress, obstructive sleep apnea, and increased inflammation of heart arteries. More inquiry with randomized controlled trials is needed to ameliorate empathize the reasons for these findings.

Medical Conditions that Interfere with Sleep

• Obstructive sleep apnea (OSA) —Symptoms of OSA include snoring or gasping for air that causes interruptions in sleep and prevention of good-quality sleep. Sleep apnea also causes oxygen levels to drib during slumber, which can pose a stress on the heart, brain and other organs. People with OSA may not exist aware that they are enkindling frequently in the night, simply do non become refreshed slumber, feeling excessively sleepy or tired during the solar day. Continuous positive airway pressure (CPAP) devices may be prescribed, which provides pressurized air to the olfactory organ and pharynx, preventing the upper airway from collapsing. Another common treatment is dental devices that move the jaw forward and increasing the airway size. Obesity is a risk factor for OSA because conveying extra weight, particularly in the cervix area, tin can contribute to obstructed animate passages. Nigh 70% of adults with OSA accept obesity, and a significant comeback in OSA is seen with weight reduction. [7] OSA is a risk factor for insulin resistance, hypertension, type 2 diabetes, cardiovascular disease, and early on mortality. [7]
• Restless leg syndrome —This condition is associated with discomfort in the legs accompanied past an urge to motility, which disrupts slumber. It is believed that aberrant levels of the neurotransmitter dopamine may be responsible, so medications are given to correct this. In some cases, depression levels of iron tin result in this disorder.
• Insomnia —This condition is defined as the disability to slumber or stay asleep. An private may have a hard time falling comatose, or may sleep simply and then awaken in the early morning and be unable to render to sleep. Brusk-term indisposition can exist caused by stress or traumatic events (divorce, task loss, expiry of a loved one). Chronic or long-term insomnia may be caused by ongoing feet, working unlike work shifts that disrupt the body's circadian rhythms, poor slumber habits, medical conditions that can interrupt sleep (chronic pain, gastroesophageal reflux affliction), or medications that have a stimulating effect. Insomnia often can be treated with behavioral therapies, although sometimes sleep medications are prescribed.
• Genetic —Studies have institute specific cistron variants that are associated with insomnia. [24,25] The aforementioned genes for insomnia were besides associated with higher levels of torso fat, low, and heart disease. Research has also found that sleep apnea clusters within families, and genes accept been identified that appear to increment take a chance for sleep apnea as well as cardiovascular disease. [26] More research is needed in this area.

What if I piece of work the night shift?

People who work overnight shifts, early on morning time shifts, or rotating shifts (both day shifts and night shifts) may develop something called shift work disorder (SWD). Studies testify that those with SWD have poorer sleep quality than day workers. [27] They may accept longer to autumn asleep, experience insomnia, and experience excessive sleepiness while awake. This is caused past attempts to sleep in daylight, which opposes natural circadian rhythms. Poor sleep hygiene further aggravates the problem. SWD is associated with decreased alertness, college risk of work-related accidents, and increased depression and feet. SWD is also associated with metabolic changes increasing the risk of heart disease, obesity, and digestive problems acquired by irregular eating habits or poor diet. The following tips can aid if you work nontraditional hours: [28]

• Request to work the aforementioned shift several nights in a row, to avoid flipping betwixt twenty-four hour period and night shift schedules on consecutive days. This helps to regulate the circadian organisation.
• Commit to a consistent slumber schedule, concealment the bedroom with blackout shades, and creating a quiet atmosphere as much as possible. You might reduce calorie-free exposure fifty-fifty earlier by wearing sunglasses as soon as you leave work. To reduce noise, clothing earplugs and use a white noise machine to block sounds.
• After finishing a night shift, endeavour to return dwelling house and become to bed as soon as possible. Running errands, watching television set, talking with family, or exercising tin re-energize your body so that falling asleep becomes more hard.
• Although information technology is tempting to run errands and attend medical appointments during the day when places are less crowded, endeavour to minimize doing them immediately after work then that you can render home and honor your sleep schedule.
• Effort to keep a set up meal schedule. Do meal planning to ensure that quick easy meals are ready when you arrive dwelling, and bring prepped meals/snacks to work for overnight shifts to prevent reliance on fast food and takeout meals. Endeavour to avoid eating a large repast right before bed, which tin increase the hazard of reflux and indigestion.

Sleep Deficiency and Eating Behaviors

Epidemiological studies testify that bereft sleep is independently associated with a higher hazard of obesity. Clinical studies of of sleep-restricted adults show an increased hunger and calorie intake when participants are allowed gratis access to food. [seven] A preference for late evening or dark food intake and increased snacking has been observed. [9] There likewise appears to be a food preference for higher saccharide and fat foods, which could partly explicate the overall higher calorie intake.

Changes in hormone levels that signal either hunger or satiety accept also been observed in clinical slumber restriction studies. Leptin is a hormone associated with satisfaction. When food enters the stomach, leptin is released from fat cells and travels to the encephalon where it signals the trunk to stop eating by creating a awareness of fullness. People with obesity may actually accept very high levels of leptin; the more than body fat one has, the more than leptin is produced in fat cells. Still, a status called leptin resistance may occur in which the brain does not receive the usual signal from leptin to stop eating. In response, more and more leptin is released. Lower leptin levels as well equally high leptin levels suggesting leptin resistance accept been observed in sleep-deprived adults. [7]

Ghrelin, the "hunger hormone," typically has the opposing action of leptin. It is released in the gut and sends hunger signals to the brain when someone is not eating plenty. About three hours after eating a meal, ghrelin levels drop. Clinical studies have found that sleep restriction leads to elevated ghrelin levels. [9]

Despite this interesting theory of poor slumber leading to changes in appetite hormone levels, other studies have found no changes and therefore the association is however inconclusive. [9] Conflicting findings may exist due to differences in the study participants (e.g., historic period, gender) and differences in how the researchers defined the elapsing and severity of sleep restriction.

How Much Sleep Do We Need?

Sleep needs modify as we age, with the average person generally requiring less sleep at older ages. Notwithstanding, specific slumber amounts vary past individual. According to the National Sleep Foundation and American University of Slumber Medicine (AASM), newborns need the most sleep, at 14-17 hours a 24-hour interval, followed by infants at 12-16 hours a day including naps. Toddlers need almost 10-14 hours a day. Preteens and teenagers need nearly 8-12 hours a night, and adults about 7-8 hours a solar day. [29] A consensus by the AASM and Sleep Research Gild recommends that adults should sleep vii or more hours a nighttime to promote optimal wellness. [30]

Despite these full general recommendations on sleep duration, individual differences in slumber requirements exist. In most epidemiologic studies, increased gamble of adverse wellness outcomes such as obesity, diabetes, and cardiovascular illness, has been observed among those who reported sleeping v hours or less per twenty-four hour period, and 9 hours or more per day. Thus, a range of slumber hours (more than 5 and less than 9) is considered advisable for near healthy adults.

Other factors such as quality of slumber are of import, because just meeting the total recommended slumber hours may not be enough if one wakes up frequently in the nighttime. A mutual conventionalities is that lost sleep from a tardily nighttime out or studying can be recovered past "sleeping in" another twenty-four hour period or taking naps. Even so, both of these methods disrupt the body's cyclic rhythms and may deprive the body of deeper sleep stages. In fact, increased variability in how much sleep we get from night to night is associated with an increased take a chance of developing metabolic and middle diseases. [31] It is important to respond, whenever possible, to the body's natural signals of sleepiness.

What virtually supplements, medicines, and other therapies for sleep?

Herbal supplements

Two pop herbal supplements, melatonin and valerian, are used as sleep aids. Melatonin has been shown to quicken time to slumber and have pocket-sized benefits on sleep duration and quality, but tin cause daytime drowsiness. It is well tolerated in adults with few reported adverse events in doses upwards to ten mg. The American Academy of Slumber Medicine (AASM) recommends the judicious use of melatonin for certain sleep and cyclic disorders such as shift work disorder or jet lag. [32]

Valerian contains small amounts of GABA, a slumber-promoting neurotransmitter, and some studies have shown that valerian can meliorate sleep. However, other studies have found no departure in sleep when taking valerian compared with placebo, and in that location appears to be minimal benefit in those who have diagnosed insomnia. The AASM does non recommend valerian for insomnia disorder. [32]

It is of import to annotation that supplements are non reviewed by the U.Southward. Food and Drug Administration for safety or effectiveness. Therefore doses and preparations of these herbs can vary widely. A study of 31 melatonin products constitute that the melatonin levels in the pills ranged between 83%-478% of the dose reported on the label. [32] More than 70% of the products varied from the labeled dose by more than 10%. If supplements are used, look for a label verifying its quality from a third-political party, such as from the U.S. Pharmacopeia.

Slumber medicines

Common medicines prescribed for sleep include sedatives such as benzodiazepines (e.g., Valium, Xanax, Klonopin, Ativan*). They help with falling asleep initially, but tend to reduce the corporeality of deeper sleep. They are not recommended for long-term use because they can worsen insomnia, increase low, and impair memory, and are associated with increased gamble of falls, cancer, and early death. [33] Long-term utilize of benzodiazepines can promote psychological dependence, and at that place is a risk of addiction and corruption. [34] Tolerance can besides develop over time, requiring larger doses to maintain their effectiveness. Because of these side effects, benzodiazepines are not recommended to care for indisposition in older adults. [34] In that location are other classes of slumber medications including non-benzodiazepines (e.g., Lunesta, Ambien) and antidepressants (e.1000., Zoloft) that also quicken the time to fall asleep but may interfere with deeper sleep stages. Anticholinergic medications (e.g., Benadryl) can increase the risk for cognitive damage and pass up. Mostly, slumber medicines are most effective when used occasionally or for a brusk time of less than one month. The American University of Slumber Medicine (AASM) recommends that cognitive behavioral therapy exist used as the initial treatment for insomnia. [*The inclusion of brand names is included for reference and does not plant an endorsement. The Nutrition Source does not endorse whatsoever specific brands.]

Other therapies

Randomized clinical trials have shown that cognitive behavioral therapies (CBT) for sleep such as minimizing napping during the twenty-four hour period, relaxation training, breathing exercises, and sleep hygiene are highly constructive and recommended as first-line treatments for insomnia. [34,32] They have been found more effective than medications for the long-term management of insomnia. People may be asked to go on a sleep journal to tape slumber habits and activities performed around bedtime, which can assist decide the most appropriate CBT.

Slumber Hygiene Tips

• Fix a sleep schedule and stick to it. Endeavour to become to bed at dark and awaken in the morning time around the aforementioned times, even on weekends. This helps to regulate the torso'south slumber cycles and circadian rhythms.
• Try to exercise at some point in the day simply avoid vigorous activity (running, fast dancing, high-intensity interval grooming or HIIT) ane hr before bedtime. Regular exercise of acceptable intensity can promote musculus relaxation and deeper slumber afterwards on.
• Endeavour to avoid large meals, heavy snacking, or alcohol two-3 hours before bed.
• If you are sensitive to caffeine, try to avoid drinking caffeinated beverages 4-6 hours earlier bedtime.
• Finish using electronic devices an hour earlier bed, especially those emitting blue light such every bit smartphones, tablets, and televisions.
• Schedule earlier-bed activities to signal that you lot are winding downwards, such as changing into pajamas and brushing teeth.
• Create a tranquility, dark, relaxing environment in your chamber. Dim the lights and plow off your jail cell phone's sound and vibration modes if possible.
• Ensure a comfortable temperature, as feeling too hot or cold can disrupt sleep.
• Create calming bedtime rituals such as practicing deep animate exercises, doing light yoga stretches, or listening to soothing relaxing music. Many meditation podcasts, apps, and YouTube videos offer these tools for gratis.
• If y'all awaken and can't render to slumber, don't stay in bed. Get up and do quiet relaxing activities, such as reading, until you lot feel tired plenty to fall dorsum asleep.

Does exercising at night disrupt sleep?

A solid body of research confirms that both aerobic and resistance exercises ameliorate sleep, with reported improvements comparable to the furnishings of pharmacological treatments for insomnia if exercises are performed regularly. [35] A review of xiii studies found that regular resistance exercises (using resistance bands, strength machines) performed 2-3 times a week for an boilerplate of one hour improved sleep quality. [36] Information technology also found that resistance exercises decreased anxiety and depression, which could be a factor in improving slumber. However, it is not recommended to do vigorous exercises such equally running or interval grooming within one hour of bedtime. A review of 23 studies constitute that healthy adults who performed high-intensity exercise besides soon before bed had difficulty falling asleep and experienced poorer slumber quality. [37] Yet, this report and others did non find that performing more than moderate exercises or exercising vigorously further away from bedtime acquired sleep disturbances, and in fact helped people to experience increased amounts of deeper slumber. [37,38]

References

1. Watson CJ, Baghdoyan HA, Lydic R. Neuropharmacology of slumber and wakefulness. Sleep medicine clinics. 2010 Dec 1;5(iv):513-28.
2. Centers for Disease Control and Prevention. Data and Statistics: Short Slumber Duration Amidst U.s.a. Adults. https://www.cdc.gov/slumber/data_statistics.html. Accessed 7/10/20.
3. Liu Y, Wheaton AG, Chapman DP, Cunningham TJ, Lu H, Croft JB. Prevalence of Healthy Sleep Duration among Adults – United States, 2014. MMWR Morb Mortal Wkly Rep. 2016;65(6):137-141. https://pubmed.ncbi.nlm.nih.gov/26890214/. Accessed 7/9/2020.
4. Healthy People 2020. Part of Disease Prevention and Health Promotion. Healthy People 2022 objective topic areas. The states Department of Health and Human Services; Washington: 2011. https://www.healthypeople.gov/2020/topics-objectives/topic/sleep-health/objectives. Accessed 7/9/2020.
5. Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between reduced sleep and weight proceeds in women. American journal of epidemiology. 2006 Nov fifteen;164(10):947-54.
6. Cooper CB, Neufeld EV, Dolezal BA, Martin JL. Sleep deprivation and obesity in adults: a brief narrative review. BMJ open sport & exercise medicine. 2022 Oct 1;four(1).
7. Koren D, Dumin Chiliad, Gozal D. Role of sleep quality in the metabolic syndrome. Diabetes, metabolic syndrome and obesity: targets and therapy. 2016;9:281.
8. St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy Yard, Hirsch J. Sleep restriction leads to increased activation of encephalon regions sensitive to food stimuli. The American journal of clinical nutrition. 2012 Apr 1;95(4):818-24.
9. Reutrakul Southward, Van Cauter E. Slumber influences on obesity, insulin resistance, and take a chance of type 2 diabetes. Metabolism. 2022 Jul 1;84:56-66.
10. Kim TW, Jeong JH, Hong SC. The impact of sleep and circadian disturbance on hormones and metabolism. International journal of endocrinology. 2022 Oct;2015.
11. Grandner MA, Seixas A, Shetty S, Shenoy S. Slumber duration and diabetes adventure: population trends and potential mechanisms. Electric current diabetes reports. 2022 November 1;xvi(11):106.
12. Covassin N, Singh P. Slumber duration and cardiovascular affliction hazard: epidemiologic and experimental evidence. Sleep medicine clinics. 2022 Mar 1;eleven(ane):81-ix.
13. Yin J, Jin X, Shan Z, Li Southward, Huang H, Li P, Peng X, Peng Z, Yu Thou, Bao Westward, Yang W. Relationship of slumber duration with all‐cause mortality and cardiovascular events: a systematic review and dose‐response meta‐analysis of prospective accomplice studies. Journal of the American Heart Association. 2022 Sep ix;vi(9):e005947.
14. Cash RE. Association Between Sleep Elapsing and Ideal Cardiovascular Health Among US Adults, National Health and Nutrition Examination Survey, 2013–2016. Preventing Chronic Disease. 2020;17.
15. Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, Rundle AG, Zammit GK, Malaspina D. Curt sleep duration as a take chances factor for hypertension: analyses of the offset National Wellness and Nutrition Examination Survey. Hypertension. 2006 May i;47(5):833-ix.
16. Ayas NT, White DP, Manson JE, Stampfer MJ, Speizer Atomic number 26, Malhotra A, Hu FB. A prospective written report of sleep duration and coronary heart disease in women. Archives of internal medicine. 2003 Jan 27;163(2):205-ix.
17. Sands-Lincoln M, Loucks EB, Lu B, Carskadon MA, Sharkey K, Stefanick ML, Ockene J, Shah Northward, Hairston KG, Robinson JG, Limacher M. Sleep duration, insomnia, and coronary center affliction amongst postmenopausal women in the Women's Health Initiative. Journal of women's health. 2013 Jun 1;22(6):477-86.
18. Li X, Sotres-Alvarez D, Gallo LC, Ramos AR, Aviles-Santa L, Perreira KM, Isasi CR, Zee PC, Savin KL, Schneiderman N, Wassertheil-Smoller S. Associations of Slumber Matted Breathing and Insomnia with Incident Hypertension and Diabetes: The Hispanic Community Health Study/Written report of Latinos. American journal of respiratory and critical care medicine. 2022 Aug 6(ja).
19. Fernandez‐Mendoza J, Shea Southward, Vgontzas AN, Calhoun SL, Liao D, Bixler EO. Insomnia and incident depression: role of objective sleep duration and natural history. Journal of sleep research. 2022 Aug;24(4):390-8.
20. National Constitute of Mental Health. Low. February 2018. https://www.nimh.nih.gov/health/topics/depression/index.shtml. Accessed 7/31/twenty.
21. Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline Southward, Resnick HE, Robbins JA, Shahar Eastward. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS med. 2009 Aug 18;vi(8):e1000132.
22. Parthasarathy S, Vasquez MM, Halonen One thousand, Bootzin R, Quan SF, Martinez FD, Guerra S. Persistent insomnia is associated with mortality run a risk. The American journal of medicine. 2022 Mar ane;128(3):268-75.
23. Liu TZ, Xu C, Rota M, Cai H, Zhang C, Shi MJ, Yuan RX, Weng H, Meng XY, Kwong JS, Sun X. Sleep elapsing and adventure of all-crusade mortality: a flexible, non-linear, meta-regression of 40 prospective accomplice studies. Sleep medicine reviews. 2022 Apr 1;32:28-36.
24. Dashti HS, Jones SE, Forest AR, Lane JM, Van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade B, Garaulet K, Kyle SD, Trivial MA, Loudon, Every bit, Luik AI, Scheer FAJL, Kpiegelhalder Kai, Tyrrell J, Gottleib DJ, Tiemeier H, Ray DW, Purcell SM, Frayling T, Redline S, Lawlor DA, Rutter MK, Weeden MN, Saxena R. Genome-broad clan study identifies genetic loci for self-reported habitual sleep duration supported past accelerometer-derived estimates. Nature communications. 2022 Mar 7;10(1):1-2. Disclosure: FAJL Scheer received speaker fees from Bayer Healthcare, Sentara Healthcare, Philips, Kellogg Company, and Vanda Pharmaceuticals. MK Rutter reports receiving research funding from Novo Nordisk, consultancy fees from Novo Nordisk and Roche Diabetes Care, and pocket-sized owning of shares in GlaxoSmithKline.
25. Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y. Biological and clinical insights from genetics of insomnia symptoms. Nature genetics. 2022 Mar;51(iii):387-93.
26. Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel Due south, Arens R, Bell GI, Beneath JE, Bjonnes AC, Chun South. Genetic associations with obstructive slumber apnea traits in Hispanic/Latino Americans. American periodical of respiratory and critical care medicine. 2022 Oct 1;194(vii):886-97.
27. Vallières A, Azaiez A, Moreau V, LeBlanc M, Morin CM. Insomnia in shift piece of work. Sleep Medicine. 2022 December 1;15(12):1440-8.
28. Shriane AE, Ferguson SA, Jay SM, Vincent GE. Sleep hygiene in shift workers: A systematic literature review. Sleep Medicine Reviews. 2022 May xx:101336.
29. Paruthi S, Brooks LJ, D'Ambrosio C, Hall WA, Kotagal Due south, Lloyd RM, Malow BA, Maski K, Nichols C, Quan SF, Rosen CL. Consensus statement of the American University of Sleep Medicine on the recommended amount of slumber for healthy children: methodology and discussion. Journal of clinical sleep medicine. 2022 Nov 15;12(11):1549-61.
30. Consensus Conference Panel, Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C. Recommended amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society. Journal of Clinical Sleep Medicine. 2022 Jun xv;11(half-dozen):591-2.
31. Huang T, Redline S. Cross-exclusive and prospective associations of actigraphy-assessed sleep regularity with metabolic abnormalities: the Multi-Ethnic Study of Atherosclerosis. Diabetes Care. 2022 Aug ane;42(viii):1422-9.
32. Zhou ES, Gardiner P, Bertisch SM. Integrative medicine for indisposition. Medical Clinics. 2022 Sep 1;101(5):865-79.
33. Markota M, Rummans TA, Bostwick JM, Lapid MI. Benzodiazepine employ in older adults: dangers, management, and alternative therapies. InMayo Clinic Proceedings 2022 November ane (Vol. 91, No. 11, pp. 1632-1639). Elsevier.
34. Brewster GS, Riegel B, Gehrman PR. Insomnia in the older adult. Sleep medicine clinics. 2022 Mar i;13(i):13-9.
35. Kredlow MA, Capozzoli MC, Hearon BA, Calkins AW, Otto MW. The furnishings of physical activity on slumber: a meta-analytic review. Journal of behavioral medicine. 2022 Jun one;38(iii):427-49. *Disclosure: MW Otto has served as a paid consultant for MicroTransponder Inc., Concert Pharmaceuticals, and ProPhase; provided expert consensus stance for Otsuka Pharmaceuticals, received royalty support for utilize of the SIGH-A from ProPhase, and received book royalties from Oxford Academy Printing, Routledge, and Springer.
36. Kovacevic A, Mavros Y, Heisz JJ, Singh MA. The effect of resistance exercise on sleep: a systematic review of randomized controlled trials. Sleep medicine reviews. 2022 Jun 1;39:52-68.
37. Stutz J, Eiholzer R, Spengler CM. Effects of evening practice on sleep in salubrious participants: A systematic review and meta-analysis. Sports Medicine. 2022 Feb 14;49(2):269-87.
38. Thomas C, Jones H, Whitworth-Turner C, Louis J. High-intensity exercise in the evening does not disrupt sleep in endurance runners. European Journal of Applied Physiology. 2022 February 1;120(2):359-68.
39. Sabia S, Fayosse A, Dumurgier J, van Hees VT, Paquet C, Sommerlad A, Kivimäki Grand, Dugravot A, Singh-Manoux A. Association of sleep duration in middle and erstwhile age with incidence of dementia. Nature Communications. 2022 Apr xx;12(i):1-0.

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